What is p53? What are its functions How does post-translational modifications

What is p53? What are its functions How does post-translational modifications

  1. Background about the p53
  2. What is p53?
  3. What are its functions
  • How does post-translational modifications of protein such as phosphorylation, acetylation and ubiquitination affect p53 functions
  1. What is the role of MDM2 protein in regulating the biochemical stability of p53 protein?
  2. What is the composition/domains within p53 protein?
  3. What are genes regulated by p53?
  • What it is essential to activate p53 in cancer
  • What are most common mutations prevalent in p53 gene
  1. How does these mutations impact p53 protein and functions?
  2. Describe the structure and the role of DNA binding domain of p53
  3. Is there a relation between various cancers and type of mutations?
  4. Describe point wise your three ideas that you want to pursue in case you get a chance to do research on p53.
  5. Describe how the functions of p53 could be detrimental on normal cells including neuron and cardiomyocytes?
  6. How will your ideas help to improve the function or knowledge of p53?

 

 

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By | 2019-05-29T13:59:13+00:00 May 29th, 2019|Uncategorized|