- Background about the p53
- What is p53?
- What are its functions
- How does post-translational modifications of protein such as phosphorylation, acetylation and ubiquitination affect p53 functions
- What is the role of MDM2 protein in regulating the biochemical stability of p53 protein?
- What is the composition/domains within p53 protein?
- What are genes regulated by p53?
- What it is essential to activate p53 in cancer
- What are most common mutations prevalent in p53 gene
- How does these mutations impact p53 protein and functions?
- Describe the structure and the role of DNA binding domain of p53
- Is there a relation between various cancers and type of mutations?
- Describe point wise your three ideas that you want to pursue in case you get a chance to do research on p53.
- Describe how the functions of p53 could be detrimental on normal cells including neuron and cardiomyocytes?
- How will your ideas help to improve the function or knowledge of p53?
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